Is it possible to monitor the Interface-Usage of only one interface & Interface-Status of all interfaces of a cisco ASR using "check_nwc"

My bad. What if you create a new dictionary for this?
Maybe another possbile way: you could write a function to “filter” the interfaces beforehand:

object Host "test" {
        check_command = "dummy"
        vars.interfaces["test-1"] = {
                usage = true
        }
        vars.interfaces["test-2"] = {
                usage = false
        }
}

apply Service "interfaces-usage" for (int => config in get_interfaces_with_usage(host.vars.interfaces)) {
        check_command = "dummy"
        vars += config
}

globals.get_interfaces_with_usage = function(interfaces) {
  var res = {}
  for (ifname => ifvalues in interfaces) {
    if (ifvalues.usage) {
        res[ifname] = ifvalues
    }
  }
  return res
}

(inspired by this post)

Just tested it and it seems to be working.

Kind regards